The recombinant human HGF is a laboratory manufactured version of Hepatocyte Growth Factor (HGF); a protein produced naturally in the human body. Recombinant DNA technology is used to manufacture HGF having functions and qualities of body produced HGF.
Recombinant HGF role in the latest Drug development
In recent times rh- HGF has had a big breakthrough in the medicinal domain. HGF is being used for healing purposes, anti-inflammatory properties, for repairing damaged organs and many more. It is long lasting and not easily breakable unlike the one produced naturally.
- Artificial HGF-Mimetic Fc Fusion
Lab-prepared HGF attached to a part of an antibody known as Fu has better healing properties. It heals liver cells and damages blood vessels and lasts longer in the body. A small peptide structure is made just like natural HGF thus known as mimicking the original. Scientists in Japan in 2024 successfully made recombinant technology through which HGF can stay in the body for much longer time without breaking.
- Plasmid HGF Gene
Rh-HGF is highly appreciated for its application in improving blood circulation in individuals suffering from reduced blood flow in legs and feet. Plasmid containing HGF gene is injected into the affected muscle and muscle cells start to produce HGF protein that is released into blood vessels.
- HGF combined with Stem cells
Together they have a number of applications. Stem cells adopt the shape of any body cell. HGF combined with stem cells shows multiple therapeutic applications. HGF guides stem cells toward the damaged parts of the body and helps it to convert into the desired tissue. Both heal the affected areas and stay longer without being ruptured.
Clinical trials using rh-HGF
- KP-100IT Drug containing rh-HGF
In Japan February 2024, 26 people suffering with neck injury were injected with rh-HGF directly into the fluids surrounding the spinal cord. The drug was named KP-100IT. Results demonstrated no side effects and the majority of the cases showed positive response with improved neck and shoulder movements.
- rh-HGF given to patients suffering from (DPN) Diabetic Periphery Neuropathy
Patients suffering from DPN are given Engenis; a gene therapy. In this the DNA encoded with instructions for synthesizing HGF is injected directly into a muscle. It helps regrow blood vessels, repair organs, muscle and work as an anti-inflammatory drug. The plasmid DNA with HGF 728 and HGF 723 gene is tested in the United states and other countries on more than 500 people.
- rh-HGF zero risk of Phenomenon
A non-viral method of delivering genes into the nucleus of someone’s body. rh-HGF plasmid method reduces viral risk to zero. Less lethal when it comes to inflammation, disease etc. rh-HGF technology is comparatively safer as compared to other healing therapies having no side effects.
HGF and Animals
Numerous experiments were carried out using recombinant HGF technology on animals before being tested upon humans. Rats were tested and diagnosed with spinal cord injury. It improved their movements and regrew the nerve fibers. Heart health of mice was improved when injected with HGF drug.
HGF in Prospective
Rh-HGF is a coming to age technology with ongoing extensive research that can revolutionize the medical world. From spinal cord to muscle healing, liver repairing to stem cell combination. Rh-HGF is an effective and diverse technology.
